<img height="1" width="1" style="display:none;" alt="" src="https://px.ads.linkedin.com/collect/?pid=3993628&amp;fmt=gif">

Translational Models of Post-Operative Pain

Increasing the predictability of your preclinical studies by using models that are relevant to the clinical situation.

 

Speak with a scientist

Post-operative Pain in Pigs for translational studies

 

Rodents have been the model of choice for the development of new treatments for acute pain, however, several limitations exist. Rodents are not useful for assessing topical and localized treatments, the anatomy of the skin differs from human skin, and healing occurs by wound contraction. Since pigs share similarities with human skin and heal by epidermal cell migration, MD Biosciences Neuro has characterized multiple porcine models for post-operative pain (POP).

 

Pig POP Models

We've discussed the benefits of the pig as a translational model. Specifically in the POP model, programs benefit in the following ways:

  • Reproducibility 
  • Mimics human condition
  • Monitoring of PK/PD 
  • Routes and volumes of administration relevant to humans 
  • Understanding of safety/PD/PK using the same animals

MD Biosciences has validated and published several pig models for post-operative pain: 

SPEAK WITH A SCIENTIST

Assessments

MD Biosciences incorporates a range of in vivo measures and endpoint assessments that provide a robust data package that enable researchers to make critical decisions. 
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

In a study, we aimed to evaluate the effect of Marcain and Exparel in the pig POP model. In additional to traditional pain assessments, we evaluate the locomotor activity of the animals. Data show open field post application in the pig POP model. 

Open Field Pig POP
 
 
Review the complete dataset.

POP datasheet

 

Download datasheet
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how translational studies can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.  



Request Proposal