Behavioral Assessments in Preclinical Models
Neurological diseases often result in a combination of motor and cognitive deficits. To gain a broader understanding of the underlying biological...
Animal Welfare in Preclinical Studies
Maintaining high standards of animal welfare in preclinical research is crucial for both ethical integrity and scientific reliability. Proper pig...
Acute Kidney Injury: Insights From In Vivo Biomarker Assessments
In vivo Acute Kidney Injury (AKI) models are commonly used to study renal damage and evaluate potential therapeutic interventions. Several models...
Behavioral Assessments in Preclinical Pain Models
Chronic pain affects 1 in 5 adults in the US, making it one of the most common chronic conditions 1. Approved analgesics often lack efficacy and have...
Importance of Diversity in Preclinical Stroke Models
The Need for Diversity in Animal Models The clinical population is diverse, including both sexes, older individuals, and those with comorbid...
Inflammatory Pain Models in Preclinical Research
Arthritic joint pain is a hallmark of inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Preclinical models are...
The Critical Role of Clinical Relevance in Effective Study Design
Enhancing clinical relevance in early-stage studies can improve efficiency, reduce costs, and guide critical decisions, ultimately advancing more CNS...
New Developments: Innovative Cold Pain Testing Methods
Cold testing in rats serves as a crucial tool in pain research, particularly in studying neuropathic pain and assessing the effectiveness of drugs....
Models of Acute Inflammatory Pain
Acute inflammatory pain is commonly associated with tissue injury and is characterized by neuronal plasticity involving both central and peripheral...