The effect of the housing environment and handling on behavior assays
An excerpt from MD Biosciences publication in the Autumn 2022 issue of Göttingen Minipigs Magazine. MD Biosciences operates a neuroscience research...
electrophysiology: an in vivo biomarker for neurology models
Animal models are commonly used in preclinical development to mimic human disease and response. Over the past several decades, drug developers have...
Preclinical Human Pain Models. Translating to Clinic
Management of acute pain related to surgical intervention, termed postoperative pain, continues to be a major problem facing physicians and patients...
A minipig Model of Incisional pain
The use of animal models for the research of post-operative pain (POP) has been well described[1]. Most POP studies that have been performed to date...
Do clinical scores tell us all we need to know?
Multiple sclerosis is a disease in which the immune system attacks the myelin sheath that covers nerve fibers. People suffering from this autoimmune...
Assessing and measuring pain behaviors in preclinical studies
Pain plays an important role in human life acting as a defense mechanism that protects us from harm. When pain becomes continuous or uncontrolled, it...
What electrophysiology brings to preclinical studies
Neurons communicate with each other as well as other muscles and organs through electrical events called action potentials and neurochemical...
Why are potential pain therapies getting lost in translation?
It is estimated that 1.5 billion people worldwide suffer from Chronic pain. While research has seen tremendous advances in our understanding of pain...
Monitoring pain in EAE animals experiencing paralysis
Many neurodegenerative diseases such as Multiple Sclerosis, ALS, and Rhett Syndrome involve paralysis. When developing new treatments, it is...