When Rodents Aren’t Enough: How Translational Pig Models Reduce Late-Stage Risk
Drug development rarely fails because a compound lacked activity. More often, it fails because preclinical models failed to predict clinical reality.
preclinical research
GLP Toxicology Studies in Neuroscience
Toxicology is a defining step between exploratory research and clinical development. As programs move toward IND-enabling requirements, the need for...
Uncovering Early Signals of Disease in EAE Models with EP
Experimental autoimmune encephalomyelitis (EAE) is one of the most widely used and well-characterized models for studying multiple sclerosis (MS)....
Critical Endpoints in Preclinical Pain Studies: Behavioral, Biomarker, and Electrophysiology Assessments
Developing effective therapeutics for pain requires selecting endpoints that accurately reflect the biological, functional, and neurophysiological...
Use of a Porcine Model for Studying Spinal Cord Injury
At this year’s Society for Neuroscience (SfN) meeting, our team presented a poster highlighting the advantages of using a porcine model to bridge the...
A Closer Look at Neuroma in Pigs and Sex-Specific Pain Responses
At the forefront of translational large-animal research, our team has developed clinically relevant pig models to study nerve injury and pain....
MD Biosciences Signs the Marseille Declaration
MD Biosciences has signed the Marseille Declaration, the first joint pharmaceutical industry statement on animal housing and use. By signing, we...
How Close Are We to Clinical Translation? Large-Animal Models for SCI
Spinal cord injury (SCI) remains one of the most challenging neurological conditions to treat, with few therapies successfully translating from the...
Approaches to Designing Preclinical Studies That Reflect Clinical Reality
Bridging the gap between preclinical and clinical research remains one of the most pressing challenges in drug development. While early-stage studies...