Importance of Diversity in Preclinical Stroke Models
The Need for Diversity in Animal Models The clinical population is diverse, including both sexes, older individuals, and those with comorbid...
translational research
Inflammatory Pain Models in Preclinical Research
Arthritic joint pain is a hallmark of inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Preclinical models are...
The Critical Role of Clinical Relevance in Effective Study Design
Enhancing clinical relevance in early-stage studies can improve efficiency, reduce costs, and guide critical decisions, ultimately advancing more CNS...
New Developments: Innovative Cold Pain Testing Methods
Cold testing in rats serves as a crucial tool in pain research, particularly in studying neuropathic pain and assessing the effectiveness of drugs....
Advancing Parkinson’s Research: Insights from Diverse Disease Models
Parkinson’s Disease (PD) is a progressive neurodegenerative movement disorder that affects millions of people worldwide. PD is characterized by the...
Inflammatory Biomarker Detection Increases Value in Early Drug Development
Inflammation is a key pathological driver in many neurological diseases. The interplay between the central and peripheral nervous systems and the...
Preclinical Efficacy Models of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapeutics agents are commonly used to treat cancer, but come with side effects such as neurotoxicity and peripheral neuropathy, which...
Promoting Diversity for Translational Success
In preclinical efficacy studies, several factors are often overlooked, and it is important to evaluate variables like sex, age, species,...