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Wound Healing

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Translational Models for Wound Healing

MD Biosciences provides advanced wound healing models in rodents and pigs to support every stage of therapeutic development. Rodent models are ideal for early-stage research, while pig models, with their human-like physiology, are optimal for assessing therapeutic efficacy and conducting GLP IND-enabling studies. MD Biosciences also runs chronic wound models, as well as aged and diabetic models, to address the impact of comorbidities on wound healing.

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Histology - incisional wound pigs
Scientific Data

Incisional Wound Histology in Pigs

The figure shows H&E staining from saline (vehicle control)-treated pigs with full-skin incisions on day 14. Figure A illustrates the epidermis (red line), dermis (D), and subcutis (SC). Figure B highlights the presence of a thin, well-defined fibrous scar that spans the dermis and subcutis.

EXPLORE RESOURCES

Advantages of the Pig as a Preclinical Model

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Innervation

Pig sensory nerve function closely mirrors human sensory function, particularly in key pain biomarkers such as TRPV1, with comparable silent nociceptor activity and nerve ending density.

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Skin Structure

Pig skin closely resembles human skin in both structure and permeability. Pig skeletal muscle aligns with human muscle in contractile, metabolic, and morphological characteristics.

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Similarity & Practicality

Pigs exhibit similarities to humans in their digestive, immune, nervous, and cardiovascular systems, making them predictive models for topical treatments, medical devices, and drug dosing studies.

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.