MD Biosciences has specialized histologists and pathologists in house. We offer highly customized processing and analysis for all tissue types for preclinical and clinical discovery. With established histological assays, IHC protocols, and unique scoring methods, we are always willing to discuss new assessments to meet your needs. All studies are run with our QC processes.
We provide advanced capabilities for in-depth assessments of tissue parameters for preclinical and clinical research and support each stage of the histology workflow from sample preparation, staining and pathologist assessment. We ensure the highest quality of data production to progress your programs forward. Our GLP histology laboratories can accommodate a variety of analyses and are equipped for all tissue types. Our expert scientists and technicians have developed and validated methodologies to facilitate a broad spectrum of studies.
Histochemistry is an important tool allowing researchers to study tissue characteristics and microscopic structures of cells. MD Biosciences has a full histological laboratory to analyze tissue samples utilizing histology and other advanced staining methods.
Routine staining methods: Hematoxylin and Eosin (H&E), Masson Trichrome (MT), PAS, Elastin, and Herovici.
Immunohistochemical (IHC) staining is used for the detection of specific cells or structures in the tissue.
MD Biosciences offers validation of antibodies and staining using variable antibodies in either paraffin sections or frozen sections according to the model, target or mode of action. The antibody may be coupled to a fluorescent marker (IF).
Super Mega slides enable sectioning of large tissues like pig heart, pig brain or large skin specimens. Super Mega slides can be scanned in high resolution.
Transverse section of minipig heart, H&E staining:
Measurements and annotations on the digital slides
Consultation of pathologists worldwide
Digital archiving
AI analysis
Demonstration of the quality of the high resolution digital scans. The digital files enable measurement and annotation on large fields and high-quality imaging.
Measurement of thermal ablation in pig skin using a digital file. Applicable measurements are length, width, area, distance between ablations.
Artificial Intelligence is used for the analysis of high-resolution digital scans of histology slides. The algorithm is trained to identify and count the required cell type or structure.
Histological analysis using algorithm-based Artificial Intelligence.
A PAS staining in mice lung tissues - for Goblet cells. In the lower panel, Goblet cells are marked in pink (upper panel is the original staining, lower panel is with AI analysis).
B IHC staining for Myelin basic protein in sciatic nerve from pig. Lower panel is the area of myelinated nerve bundles marked in pink (upper panel is the original staining, lower panel is with AI analysis).
C Active microglia cells (Iba-1 positive) are identified and counted by the algorithm in several fields.
MD Biosciences provides an extensive list of biomarkers for clinical discovery, including histology and immunohistochemistry. We also offer novel biomarker validation.
We provide other clinical biomarker services. For a full list of assays, click here
Gallery of Staining
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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.
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