Behavior
Conduct extensive pain, sensory, motor, and cognitive behavioral testing.
MD Biosciences provides well-characterized stroke models, including rodent models for focal ischemia (permanent and transient MCAo) and global ischemia (4VO). These models closely replicate human stroke, offering essential insights into injury mechanisms, cell damage, and drug efficacy in targeting neurodegeneration and neuroinflammation.
The focal cerebral ischemic model (MCAo) of stroke is a widely used model for assessing ischemic brain injury. By occluding the middle cerebral artery, this model reduces cerebral blood flow, affecting both the striatum and cortex, and mimicking focal brain damage observed in human stroke. Transient occlusion is where the artery is temporarily blocked before reperfusion while permanent occlusion causes extensive damage.
The global ischemia model involves the permanent occlusion of vertebral arteries and the transient occlusion of carotid arteries, leading to brain injury in the hippocampus due to reduced cerebral blood flow. This model mimics conditions such as cardiac arrest and coronary bypass surgery, and is used to evaluate the effects of reduced blood flow to the brain. It also helps assess neurodegeneration, dementia, and oxidative stress.
The figure shows grip test results in the MCAo stroke model, revealing significant differences between young and aged males, as well as between aged males and aged females.
MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
Conduct extensive pain, sensory, motor, and cognitive behavioral testing.
Explore inflammatory and pain biomarkers in disease-specific tissues.
Characterize tissue and cellular changes in disease, pain, and neurodegeneration.