EAE Multiple Sclerosis Research

Advancing Preclinical Research with EAE Models

MD Biosciences provides a comprehensive suite of well-characterized Experimental Autoimmune Encephalomyelitis (EAE) rodent models to advance inflammation and multiple sclerosis research. Our MOG, PLP, and MBP EAE models deliver actionable insights for therapeutic development, supported by advanced assessments that enhance translational relevance.

MOG-EAE Model

The myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE) model is widely used to study chronic, progressive forms of multiple sclerosis. MOG, a key protein in myelin, triggers immune responses that lead to demyelination, motor impairment, and paralysis in rodent models. This model closely mimics many aspects of human multiple sclerosis, offering valuable insights into disease progression.
PLP-EAE Model
MBP-EAE Model

The myelin basic protein (MBP)-induced EAE model is a valuable tool for studying acute relapses in multiple sclerosis. A single dose of MBP induces transient hind paw paralysis, mimicking early-stage MS-like episodes. Histological analysis highlights mononuclear cell infiltration and foci formation in the cervical spinal cord, without demyelination, making this model ideal for investigating early inflammatory events in multiple sclerosis.

Scientific Data

Electrophysiology in EAE

The figure shows motor evoked potentials in naïve, mild, and severe EAE models. Electrophysiological characterization shows how early EAE causes desynchronized neural activity and hypersensitivity, leading to motor and sensory loss in later stages.

EXPLORE RESOURCES

Behavior

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

Electrophysiology

Measure motor and sensory evoked potentials to assess disease progression and pain.

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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoint assessments. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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About Us

Cell-based Assays

Efficacy Models

Assessments

PK/PD & Toxicology

Pain

Neurodegeneration

Neuroinflammation

Wound Healing

Content

Whitepapers:

About Us

Cell-based Assays

Efficacy Models

Assessments

PK/PD & Toxicology

Pain

Neurodegeneration

Neuroinflammation

Wound Healing

Content

Whitepapers:

EAE Multiple Sclerosis

Advancing Preclinical Research with EAE Models

MOG-EAE Model

PLP-EAE Model

MBP-EAE Model

Scientific Data

Electrophysiology in EAE

Assessments

Behavior

Biomarkers

Histology

Electrophysiology

Explore our Resources

Datasheet

Publication

Webinar

Whitepaper

Whitepaper

Whitepaper

READY TO DISCUSS YOUR PROGRAM?