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Acute Inflammatory Pain

The CFA-induced and Carrageenan-induced inflammatory pain models.

Pain associated with tissue injury

Acute Inflammatory pain is commonly associated with tissue injury and manifests itself as an expression of neuronal plasticity consisting of central and peripheral sensitization. Tissue injury causes a release of inflammatory mediators from damaged cells, which become central to the initiation of an inflammatory cascade. 

MD Biosciences offers acute inflammatory pain models that can be extended to evaluate a more chronic inflammatory pain state. In models like CFA or carrageenan, we can measure the release of cytokines and their role in the initiation and maintenance of the inflammatory response.

 

Acute inflammatory pain models:

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Scientific Data

Biomarkers are used to analyze pro-inflammatory and anti-inflammatory cytokines in paw skin, CSF, and plasma. Analysis of these sample types provide information on local and systemic effects of a drug.

Biomarkers in CFA-induced inflammatory pain (800 × 500 px)
 

CFA datasheet

 

Download datasheet

Assessments

Inflammatory biomarkers provide information related to mechanisms contributing to inflammatory pain and how well compounds modulate the inflammatory and/or pain response.
Pain behavioral anaysis

Behavior 

Pain behavior tests include dynamic weightbearing and Hargreaves to assess the distribution on each paw and sensitivity to heat.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
 

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