Translational model of Neuropathic Pain

Neuropathic Pain model in Pigs

Preclinical rodent models largely contribute to our understanding of chronic neuropathic pain, however these animal models are limiting due to poor clinical translation. Since pigs share similarities with humans, such as skin innervation and neurological resemblance, MD Biosciences developed a pig model for chronic pain caused by surgically-induced peripheral neuritis (PNT) (Castel et al., 2016). In the model, 75% of animals exhibit mechanical and tactile allodynia by day 28 post surgery, demonstrating painful neuropathy. We also showed that positive controls inhibited hypersensitivity to von Frey filaments and feather stimuli, reversing spontaneous pain-related behavior in a dose-related manner.