MD Biosciences excels in addressing critical gaps in inflammation and pain research. We offer a diverse selection of inflammatory pain models, ranging from acute inflammatory pain to chronic pain associated with arthritic conditions. Additional readouts, such as biomarker analysis and histology are available and integrated into our studies.
Models of Inflammatory Pain
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Acute Inflammatory Pain Models
CFA and carrageenan-induced models are essential for studying acute and chronic inflammatory pain resulting from tissue injury. The CFA model involves peripheral tissue injury through the injection of CFA, while the carrageenan model induces a short-lasting acute inflammation and hyperalgesia. These models, available in both mice and rats, allow for the assessment of cytokine release to understand their roles in initiating and sustaining inflammation.
Learn more about our acute inflammatory pain models.
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Arthritic Joint Pain
The monosodium iodoacetate (MIA) and collagen-induced arthritis (CIA) models are used to evaluate arthritic pain. These models include both inflammatory and neuropathic pain components. We provide models in rats and joint inflammation models in pigs, enabling comprehensive studies of pain mechanisms.
Learn more about our osteoarthritis models.
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Post-operative Pain
We provide advanced models for studying post-operative pain in both rats and pigs. The Brennan rodent model of paw incisional pain is widely used to evaluate post-operative pain. Additionally, our pig model serves as a highly translational tool for pain therapeutics, thanks to its close anatomical and physiological similarities to humans.
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Spinal Cord Injury
We offer a range of in vitro and in vivo models for evaluating spinal cord injury. Our in vivo models include spinal cord injury in rats induced by contusion, cutting, or extraction. Spinal cord injuries frequently result in sensory impairments, severe motor dysfunction (including paralysis), and chronic pain, making these models crucial for addressing complex research challenges.
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At MD Biosciences, we’re not just a service provider—we’re your dedicated partner in drug development. With industry-leading expertise, we offer tailored study designs, translational models, and comprehensive endpoint assessments. Our commitment to short lead times and competitive pricing, combined with our deep scientific knowledge, ensures your research progresses efficiently and effectively. Collaborate with us to turn your scientific vision into reality.