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Neuropathic Pain

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Advancing Preclinical Research with Neuropathic Pain Models

MD Biosciences provides specialized pig and rodent models tailored for preclinical pain research, with a focus on neuropathic pain resulting from peripheral nervous system injury. Discover our comprehensive models and assessments, designed to advance the understanding of pain mechanisms and support the development of effective therapies.
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Pig Model Peripheral Nerve Repair
Scientific Data

Gait Analysis in Neuroma Pig Model

The figure shows body load distribution in the symptomatic neuroma pig model. Two months after surgery, pigs carry more weight on the intact hind leg compared to the operated hind leg.

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PNT Model in Pigs
Scientific Data

Von Frey in Peripheral Neuritis Trauma Model

The figure shows responses to von Frey testing in PNT pigs treated with various interventions. Fourteen days post-PNT, gabapentin increases withdrawal thresholds in a dose- and time-dependent manner, while Aprepitant shows no effect, consistent with human data.

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STZ Neuropathic Pain
Scientific Data

Sex Differences in STZ-Induced Neuropathic Pain

The figure shows pain responses to von Frey testing in the STZ model, revealing differences between males and females. In males, the response remains steady, while in females, the response is smaller, reverses on day 25, and decreases on day 28.

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Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

electrophysiology

Electrophysiology

Measure motor and sensory evoked potentials to assess disease progression and pain.

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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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