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Post-Operative Pain

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Advancing Preclinical Research with Post-Operative Pain Models

MD Biosciences provides specialized models for post-operative pain (POP), including the Brennan paw incision model in rodents and our advanced translational pig model. The pig shares valuable similarities with humans, such as skin and neurological characteristics, making it an exceptional choice for studying post-surgical pain. Our state-of-the-art facilities and expert team provide a multifaceted approach with clinically relevant assessments, including histology, immunohistochemistry (IHC), biomarker analysis, behavioral assessments, and in vivo electrophysiology. Explore our comprehensive models and assessments designed to deepen the understanding of post-operative pain and drive the development of effective therapies.
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Open Field_POP Pigs
Scientific Data

Open Field Assay in Pig POP Model

The figure shows locomotor activity in the pig POP model at baseline and 2 hours post-treatment. Open field traces indicate a significant reduction in activity for both treatments compared to the vehicle group.

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VF_POP Rodents
Scientific Data

Von Frey in Rodent POP Model

The figure shows withdrawal force decreases after incision in both vehicle and treated groups, indicating increased sensitivity.

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Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

electrophysiology

Electrophysiology

Measure motor and sensory evoked potentials to assess disease progression and pain.

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READY TO DISCUSS YOUR PROGRAM?

MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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