MD Biosciences provides PK services for rodents and pigs, and designs studies that optimize sample collection and analytics. Below is a list of our PK services:
Standard PK
Dose linearity PK
CNS penetration
Tissue distribution
Formulation screening
Bioanalysis services: sample analysis by LC-MS/MS of biofluids or tissues
Toxicology
Toxicology studies are crucial in assessing drug safety. At MD Biosciences toxicology studies are performed in rodents or pigs and are GLP and regulatory compliant. We assist with the study design and consider components like dosing route/regimen and dosing levels. Common readouts include clinical signs, body weight, clinical pathology, organ weights, gross pathology, histopathology and biomarkers. Samples are collected throughout the study for downstream analysis, and tissues are collected for necropsy and pathology. Additionally, we can streamline the regulatory process through our expertise in SEND data standardization and eCDT tables.
PK: plasma concentration following administration of a single clonidine film.
Plasma Cmax was 279±50.1 pg/mL at 24 hours, falling to 149±26 pg/mL at 72 hours.
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At MD Biosciences, we’re your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoint assessments. With short lead times, competitive pricing, and deep scientific expertise, we help move your research forward efficiently.
