Sample Data

• Rodent PK/PD Data

  PK and tissue distribution in mice: comparison between IV and PO route of administration in mice.

  GI data below. Collection feces can reflect the pharmokinetics in the GI.

   

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  Pharmacokinetics in other organs.

    

  

   

• Pig PK/PD Data

  PK: systemic exposure of ropivicaine following local administration. Long exposure following PRF-108 treatment.

  

  Ropivicaine concentration in wound fluid at 48 hours post local administration.

  

  PD: long-acting activity of PRF-108 following local administration (ropivacaine formulation).

  

  PK of buprenorphine in pigs following 0.2 mg/kg  administration using IM route

  

  

  Review our publication: 

  Castel D, Naveh M, Aharon A, Doron O, Meilin S. Prolonged Analgesic Effect of PRF-108 and PRF-110 on Post-operative Pain in Pigs. Pain Ther. 2016;5(1):29-42. doi:10.1007/s40122-015-0043-9

   

   

• Pig Toxicology Data

  Exparel (106.4  per pig)

  Bupivacaine effect on pain relief:

  

  Bupivacaine plasma concentration:

  

   

  Toxicology of the injected site (magnification X 2):

  

  Key for arrows:

  Green arrows indicate the relatively thin and well-defined immature granulation tissue which extends through the dermis.

  Red arrows indicate the relatively wider extension of the immature granulation tissues in the subcutis.

  Bupivicaine PK data:

  

   

  Clonidine testing

  Review the publication: Wilsey JT, Block JH. Sustained analgesic effect of clonidine co-polymer depot in a porcine incisional pain model. J Pain Res. 2018;11:693-701. Published 2018 Apr 9. doi:10.2147/JPR.S157018

   

   

  

  

   

  PK: plasma concentration following administration of a single clonidine film.

  

  Plasma Cmax was 279±50.1 pg/mL at 24 hours, falling to 149±26 pg/mL at 72 hours.