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Acute Kidney Injury

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Advancing Preclinical Research with Acute Kidney Injury Models 

The Acute Kidney Injury (AKI) model is commonly used to study renal dysfunction. AKI is induced through nephrectomy of one kidney followed by occlusion of the second kidney for 45-50 minutes. MD Biosciences developed a pig model for AKI, leveraging the similarities pigs share with humans in organ function and drug response. Pig physiological characteristics, such as comparable kidney size and function, enhance the relevance of this model in assessing renal dysfunction and testing potential therapeutic interventions.
Blood biomarker levels AKI
Scientific Data

Blood Biomarkers in AKI Pig Model

The figures show blood creatinine and urea concentrations following AKI increase over time indicating declining kidney function.

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Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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