Behavior
Conduct extensive pain, sensory, motor, and cognitive behavioral testing.
MD Biosciences offers specialized neurodegeneration assays and rodent models for preclinical spinal cord injury (SCI) research, focusing on sensory impairment, motor dysfunction, and chronic pain. We provide various in vitro and in vivo models for SCI, including transection, contusion, and extraction, all performed by our expert surgeons. Our state-of-the-art facilities and highly skilled team provide a multifaceted approach with clinically relevant assessments, including histology, immunohistochemistry (IHC), biomarker analysis, behavioral assessments, and in vivo electrophysiology.
Explore our comprehensive models and assessments designed to deepen the understanding of SCI mechanisms and drive the development of effective therapies.
The neurodegeneration screening assay utilizes primary neurons from adult rat spinal cord tissues, plated in media and incubated with a to study sensory and motor deficits, inflammation, and tissue repair processes. This model helps evaluate treatments designed to improve functional recovery and reduce chronic pain. Advanced assessments include behavioral evaluations, electrophysiological measurements, and tissue analysis for comprehensive outcome evaluation.
The spinal cord injury model in rats is created through contusion, transection, or compression to study sensory and motor deficits, inflammation, and tissue repair processes. This model helps evaluate treatments designed to improve functional recovery and reduce chronic pain. Advanced assessments include behavioral evaluations, electrophysiological measurements, and tissue analysis for comprehensive outcome evaluation.
This figure presents catwalk analysis of the left and right paws over 12 weeks in the SCI contusion model. Female animals exhibited better recovery compared to male animals.
MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
Conduct extensive pain, sensory, motor, and cognitive behavioral testing.
Explore inflammatory and pain biomarkers in disease-specific tissues.
Characterize tissue and cellular changes in disease, pain, and neurodegeneration.
Measure motor and sensory evoked potentials to assess disease progression and pain.