Neuromas form because of disorganized sensory axonal regeneration following nerve injury. Painful neuromas lead to poor quality of life for patients and place a burden on healthcare systems. Modern surgical interventions for resolve neuromas entail dissection of the affected nerve in the proximal end and guided regeneration of sensory nerve fibers into denervated muscle tissue (Regenerative Peripheral Nerve Interface- RPNI). However, one question remained unclear: whether the neuroma should be removed or not.
