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MOG-Induced EAE

Preclinical Model of Multiple Sclerosis and Autoimmune Neuroinflammation

 

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MOG-induced EAE Efficacy Model for MS Research

 

Experimental autoimmune encephalomyelitis (EAE) is primarily used as a non-clinical model of autoimmune inflammatory diseases of the CNS, and resembles many aspects of human Multiple Sclerosis (MS). The myelin oligodendrocyte glycoprotein (MOG)-induced EAE model is ideal for exploring this immune-mediated mechanism of neuroinflammation and demyelination. Our MOG-induced EAE model is well-characterized and commonly used in the development of a variety of MS therapeutics. MDB also provides OECD GLP-certified clinical batch release testing services for Copaxone® generics (Glatiramer Acetate). 

At MD Biosciences, the Multiple Sclerosis efficacy model contains immunization with Myelin Oligodendrocyte Glycoprotein (MOG35-55), which induces a chronic form of EAE in mice.

Assessments

Inflammatory biomarkers provide information related to mechanisms contributing to inflammatory pain and how well compounds modulate the inflammatory and/or pain response.
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in tissue samples. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Cytokines by multiplex analysis. Two markers from a cytokine profile in MOG-induced animals that were treated with vehicle or positive control. Day 15 was compared to day 26.

Biomarkers - MOG EAE - MDB
 
 
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EAE datasheet

 

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READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

 

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