<img height="1" width="1" style="display:none;" alt="" src="https://px.ads.linkedin.com/collect/?pid=3993628&amp;fmt=gif">

Arthritic Inflammatory Pain

At MD Biosciences, we offer the monosodium iodoacetate (MIA) model for osteoarthritis pain, and the collagen-induced arthritis (CIA) model for rheumatoid arthritis pain. These models include both inflammatory and neuropathic pain components. We provide models in rats and joint inflammation models in pigs, enabling comprehensive studies of pain mechanisms. 

 

Inflammatory Pain Models:

Scientific Data

Response to von Frey in the rat MIA-induced OA model. Positive controls have an increased withdrawal 14 days after treatment. 

MIA_Von Frey_rats
 
 
Review the complete dataset.

MIA Datasheet

 

Download datasheet

Assessments
Pain behavioral anaysis

Behavior 

Pain behavior tests include dynamic open field, weight bearing or limp score, hyperalgesia and others dependent on species.
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

Request Proposal