Behavior
Conduct extensive pain, sensory, motor, and cognitive behavioral testing.
Neurotoxicity and peripheral neuropathy are standard side effects of agents used for chemotherapy. A side effect is peripheral neuropathy and is a limiting factor for dose levels required for anti-tumor effects.
A hallmark of degeneration is the blebbing of neurites, which is when neurites begin disassembly and degeneration. The neurodegeneration index (NI) compares the relative area of neurites and the number of neurites.
The CIPN in vitro screening assay overview: Dorsal root ganglion (DRG) neurons were cultured from adult rats. Cultures are treated for 5 days with a chemotherapeutic agents followed by treatment with compound. Cultures are stained with beta-tubulin III antibody and measured for neurodegeneration index.
The assays are ideal for screening compounds prior to efficacy in in vivo studies.
MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
Conduct extensive pain, sensory, motor, and cognitive behavioral testing.
Explore inflammatory and pain biomarkers in disease-specific tissues.
Characterize tissue and cellular changes in disease, pain, and neurodegeneration.