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Chronic Post-Ischemia Pain

A preclinical model for Complex regional pain syndrome (CRPS). 

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A Novel Preclinical Animal Model of Complex Regional Pain Syndrome Type I (CRPS-I)

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Type II is when there is known associated nerve injury. Neuropathic inflammation, specifically activation of peripheral nociceptors of C-fibers, has been shown to play a critical role in developing CRPS. One of the models for CRPS is Chronic Post Ischemia Pain Model.
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CPIP Von Frey
Scientific Data

Von Frey in CPIP Rat Model

Von Frey measured in CPIP rat model shows a decrease in withdrawal force in the CPIP treated rats.

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Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

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MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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