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Chronic Post-Ischemia Pain

A preclinical model for Complex regional pain syndrome (CRPS). 

A novel preclinical animal model of complex regional pain syndrome- type I (CRPS-I)

 

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Type II is when there is known associated nerve injury. Neuropathic inflammation, specifically activation of peripheral nociceptors of C-fibers, has been shown to play a critical role in developing CRPS. One of the models for CRPS is Chronic Post Ischemia Pain Model.

 

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SCIENTIFIC DATA

Von Frey measured in CPIP rat model shows a decrease in withdrawal force in the CPIP treated rats.

CPIP Von Frey

 

 

 

 

 
 
 

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