Chronic Post-Ischemia Pain

A Novel Preclinical Animal Model of Complex Regional Pain Syndrome Type I (CRPS-I)

Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into CRPS-I and CRPS-II. Type I occurs when there is no confirmed nerve injury. Type II is when there is known associated nerve injury. Neuropathic inflammation, specifically activation of peripheral nociceptors of C-fibers, has been shown to play a critical role in developing CRPS. One of the models for CRPS is Chronic Post Ischemia Pain Model.