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Distal Tibial Injury (DTI)

A preclinical peripheral nerve injury model for neuropathic pain. 

 

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Preclinical Neuropathic Pain Model

In the distal tibial injury model, the tibial nerve is dissected and severed as close to its distal end as possible, ensuring avoidance of the popliteal vessels. While many existing models tend to focus on proximal nerve injuries, this models addresses injuries occurring in the distal extremities. In clinical practice, the majority of nerve injuries affect the distal extremities rather than proximal regions. This model directly reflects this clinical reality, ensuring its relevance and practicality in real-world scenarios.



Model Specifications

  • Model Length: several weeks
  • Readouts: von Frey, hot plate, cold plate, gait analysis
  • Endpoints: biomarkers, histology/IHC, electrophysiology
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Assessments

Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. 

 
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Response using Von Frey in the DTI Model.

 

Von Frey
 
 
Review the complete dataset.

Nerve injury datasheet (1)

 

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