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Sciatic Nerve Crush

Peripheral Nerve Injury Model of Neuropathic Pain

Assessment of Nerve Regeneration

 

Neuropathic pain may arise from many different disease states and present with a variety of symptoms, including shooting or burning pain, tingling, numbness, and allodynia. Clinically significant relief is often difficult to achieve, in part because conventional opioid therapy is typically less effective for neuropathic pain. Understanding the mechanisms and underlying neuropathic pain syndromes is crucial to the development of more effective therapies.

Model Specifications

  • Species: Mouse or Rat
  • Model length: up to 31 days
  • Readouts: tactile allodynia, cold allodynia
  • Endpoints: histology, biomarker analysis (protein or mRNA levels)

 

Assessments

Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. 
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Pain response using Von Frey in the nerve crush model. 

Crush_Von_Frey
 
 
Review the complete dataset.

Nerve injury datasheet (1)

Download datasheet
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

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