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Spared Nerve Injury

Peripheral Nerve Injury (PNI) Models of Neuropathic Pain

Spared Nerve Injury Model of Peripheral Neuropathic Pain

 

The Spared Nerve Injury (SNI) model is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve. It is commonly used to study neuroma that forms at 28 days following surgery. 

 

Model Specifications

  • Species: Rat 
  • Length: 14-15 days 
  • Assessments: Dynamic Weight bearing, Catwalk analysis, Electrophysiology, Histology

Assessments

Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. 
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.

Scientific Data

Response using Von Frey in the SNI Model.

Response using Von Frey in the SNI Model
 
 
Review the complete dataset.

Nerve injury datasheet (1)

Download datasheet
 

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