<img height="1" width="1" style="display:none;" alt="" src="https://px.ads.linkedin.com/collect/?pid=3993628&amp;fmt=gif">

Neuroma

A large animal model of symptomatic neuroma mimicking the clinical situation. 

 

 

Speak with a scientist

Symptomatic Neuroma Model in Pigs

A neuroma develops when a nerve is damaged, resulting in a mass formation at the site of injury. This neuroma may be symptomatic and lead to persistent pain, tingling, or burning sensations along the nerve’s pathway. The symptomatic neuroma model involves peroneal nerve dissection.



Model Specifications

  • Species: Domestic Pig or Göttingen Minipig
  • Duration: 28 days, up to 6 months
  • Readouts: tactile/mechanical allodynia, thermal hyperalgesia, gait analysis, behavior score, body weight, electrophysiology
  • Endpoints: histology, biomarker analysis, IHC
Speak with a scientist

Scientific Data

Gait analysis in the symptomatic neuroma model. The pig carries more weight on the intact hind leg than the operated hind leg 2 months after surgery.

Gait analysis
 
 
Review the complete dataset.

 

neuroma1

 

Download datasheet

Assessments

Neurological disorders often result in a combination of motor and cognitive deficits. Thus, behavioral assessments in conjunction with physiological readouts offer a broader understanding of the basic biological mechanism of disease and cognitive impairment, highly relevant to therapeutic developments. 

 
Pain behavioral anaysis

Behavior 

Pain behavior tests assess the response to various pain stimuli.  
biomarker

Biomarkers

Evaluate pro-inflammatory and anti-inflammatory biomarkers from CSF samples. 
histology

Histology

IHC and histological staining to evaluate inflammatory markers in the paw skin. 
electrophysiology

Electrophysiology

Evaluate spontaneous nerve firing using in vivo electrophysiology.
 

READY TO DISCUSS YOUR PROGRAM?

If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.

Request Proposal