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Translational Pig Models

Bridging the gap between preclinical and clinical studies

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mdbiosciences-neurology-leading-preclinical-CRO-1

The importance of efficacy studies performed in large animal models of pain.

One of the challenges in the life sciences industry is improving the approval rate of neurology and pain treatments. While our understanding of neurology is growing, there are still several limitations. Compared to other therapeutic areas, there are fewer predictive models, fewer known biomarkers that help quantify disease, and a narrow scope of human data. Consequently, the development of neurological treatments heavily depends on qualitative and subjective measures, which is an inadequate predictor of disease and treatment. MD Biosciences is combatting this challenge by developing translational models and novel quantitative measures that help de-risk clinical trials. 

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Advantages of the Pig as a Preclinical Model

Increasing the clinical translatability of preclinical data requires models that accurately reflect the human condition. The pig shares valuable similarities with humans, including skin and neurological characteristics. Additionally, studies in the pig are more relevant for topical treatments, closely mimic human drug dose volumes, allow evaluation of medical devices, exhibit nerve stimulation and behavioral changes that closely resemble humans, and have similarity in >93% of relevant biomarkers.

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Innervation

Pig sensory nerve function closely mirrors human sensory function, particularly in key pain biomarkers such as TRPV1, with comparable silent nociceptor activity and nerve ending density.

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Skin Structure

Pig skin closely resembles human skin in both structure and permeability. Pig skeletal muscle aligns with human muscle in contractile, metabolic, and morphological characteristics.

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Similarity & Practicality

Pigs exhibit similarities to humans in their digestive, immune, nervous, and cardiovascular systems, making them predictive models for topical treatments, medical devices, and drug dosing studies.

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Translational Models offered by MD Biosciences

As a leading preclinical CRO in neurodegeneration and pain research, we have developed several translational models in the pig. See our published work here. 

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Clinically Relevant Assessments

MD Biosciences offers comprehensive in vivo measures and endpoint assessments, delivering robust data packages to support critical research decisions in the evolving landscape of drug development and biomedical research.
behavior

Behavior 

Conduct extensive pain, sensory, motor, and cognitive behavioral testing.

biomarker

Biomarkers

Explore inflammatory and pain biomarkers in disease-specific tissues.

histology

Histology

Characterize tissue and cellular changes in disease, pain, and neurodegeneration.

electrophysiology

Electrophysiology

Measure motor and sensory evoked potentials to assess disease progression and pain.

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READY TO DISCUSS YOUR PROGRAM?

MD Biosciences is your dedicated partner in drug development, offering tailored study designs, translational models, and comprehensive endpoints. With short lead times, competitive pricing, and deep scientific expertise, we help move your pipeline forward efficiently.

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