Neuroinflammation and neurodegeneration
Neuroinflammation often begins with the activation of cellular immune components such as microglia and astrocytes, which mediate the release of inflammatory molecules. The over and under expression of pro- and anti-inflammatory cytokines alters the homeostasis of the CNS and may contribute to a progressive dysfunction and loss of neurons in the CNS. This may lead to neurodegeneration, peripheral neuropathy, or other forms of pain.
MD Biosciences offers preclinical models of neurodegeneration and biomarkers to assess neuroinflammation involved in or as a result of damage to neurons.
Neuroinflammation and Pain
At the anatomical level, neuro-immune interactions have been shown to take place all along the pain processing pathway. This is partially facilitated by increased permeability of the blood-brain barrier following SCI or peripheral nerve injury. At the cellular level, neuro-immune interactions involve leukocytes like mast cells, neutrophils, macrophages, and T cells. They also involve glial cells with immune-like functions including Schwann cells, satellite glial cells in the PNS, and microglia and astrocytes in the CNS.
MD Biosciences offers pain models and biomarkers to assess neuroinflammation involved in or as a result of chronic pain.
READY TO DISCUSS YOUR PROGRAM?
If you are ready to discuss how a partnership can fit into your development program, our scientists are eager to explore the possibilities with you. Like many other pharmaceutical and medical device developers, you can rely on predictive preclinical data.
